Abstract
Background: The prevalence of Alzheimer disease (AD) is expected to increase, especially in Indonesia. Despite lacking a cure, extra-virgin olive oil, abundant in neuroprotective compounds, offers promise in delaying cognitive decline by opposing oxidative stress in the aging brain. Research indicates its capacity to bolster long-term cognitive function and memory. Objectives: We examined the impact of olive oil and its derivatives on AD through a comprehensive analysis of experimental studies in mouse and worm models. Materials & Methods: Thirteen relevant articles were selected from the initial pool based on specific inclusion criteria. Data were extracted regarding study design, intervention types, model species used, cognitive outcomes, and findings. The reliability of the selected studies was ensured by evaluating their methodological quality and risk of bias. Results: Our systematic review of 13 selected experimental studies involving mice and worm models provides insights into the potential impact of olive oil and its extracts on AD. Findings suggest that these interventions may exhibit neuroprotective properties, positively influencing cognitive function and mitigating AD-related outcomes in the experimental models studied. Conclusion: Experimental studies on mice and worm models suggest that olive oil and its extracts may present neuroprotective benefits and positively influence cognitive function in AD contexts. Further research involving human subjects is essential to validate these findings and explore their practical implications in AD prevention and management.
| Original language | English |
|---|---|
| Pages (from-to) | 266-277 |
| Number of pages | 12 |
| Journal | Caspian Journal of Neurological Sciences |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 2024 |
Keywords
- Alzheimer disease
- Dementia
- Experimental animal models
- Olive oil
- Systematic review
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Sugondo, A. T., Salfi, Q. N., Ramadhani, M. T., Puspamaniar, V. A., Machin, A. (2024). Olive Oil and Its Extracts in Alzheimer's Disease: A Systematic Review in Animal Models. Caspian Journal of Neurological Sciences, 10(4), 266-277. https://doi.org/10.32598/CJNS.10.39.471.1
Sugondo, Alexander Tikara ; Salfi, Qorina Nadya ; Ramadhani, Maura Tuzzahrah et al. / Olive Oil and Its Extracts in Alzheimer's Disease : A Systematic Review in Animal Models. In: Caspian Journal of Neurological Sciences. 2024 ; Vol. 10, No. 4. pp. 266-277.
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title = "Olive Oil and Its Extracts in Alzheimer's Disease: A Systematic Review in Animal Models",
abstract = "Background: The prevalence of Alzheimer disease (AD) is expected to increase, especially in Indonesia. Despite lacking a cure, extra-virgin olive oil, abundant in neuroprotective compounds, offers promise in delaying cognitive decline by opposing oxidative stress in the aging brain. Research indicates its capacity to bolster long-term cognitive function and memory. Objectives: We examined the impact of olive oil and its derivatives on AD through a comprehensive analysis of experimental studies in mouse and worm models. Materials & Methods: Thirteen relevant articles were selected from the initial pool based on specific inclusion criteria. Data were extracted regarding study design, intervention types, model species used, cognitive outcomes, and findings. The reliability of the selected studies was ensured by evaluating their methodological quality and risk of bias. Results: Our systematic review of 13 selected experimental studies involving mice and worm models provides insights into the potential impact of olive oil and its extracts on AD. Findings suggest that these interventions may exhibit neuroprotective properties, positively influencing cognitive function and mitigating AD-related outcomes in the experimental models studied. Conclusion: Experimental studies on mice and worm models suggest that olive oil and its extracts may present neuroprotective benefits and positively influence cognitive function in AD contexts. Further research involving human subjects is essential to validate these findings and explore their practical implications in AD prevention and management.",
keywords = "Alzheimer disease, Dementia, Experimental animal models, Olive oil, Systematic review",
author = "Sugondo, {Alexander Tikara} and Salfi, {Qorina Nadya} and Ramadhani, {Maura Tuzzahrah} and Puspamaniar, {Vania Ayu} and Abdulloh Machin and Yudha Haryono",
note = "Publisher Copyright: {\textcopyright} 2024 The Author(s); This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC: https://creativecommons.org/licenses/by-nc/4.0/ legalcode.en), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.",
year = "2024",
month = oct,
doi = "10.32598/CJNS.10.39.471.1",
language = "English",
volume = "10",
pages = "266--277",
journal = "Caspian Journal of Neurological Sciences",
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Sugondo, AT, Salfi, QN, Ramadhani, MT, Puspamaniar, VA, Machin, A 2024, 'Olive Oil and Its Extracts in Alzheimer's Disease: A Systematic Review in Animal Models', Caspian Journal of Neurological Sciences, vol. 10, no. 4, pp. 266-277. https://doi.org/10.32598/CJNS.10.39.471.1
Olive Oil and Its Extracts in Alzheimer's Disease: A Systematic Review in Animal Models. / Sugondo, Alexander Tikara; Salfi, Qorina Nadya; Ramadhani, Maura Tuzzahrah et al.
In: Caspian Journal of Neurological Sciences, Vol. 10, No. 4, 10.2024, p. 266-277.
Research output: Contribution to journal › Review article › peer-review
TY - JOUR
T1 - Olive Oil and Its Extracts in Alzheimer's Disease
T2 - A Systematic Review in Animal Models
AU - Sugondo, Alexander Tikara
AU - Salfi, Qorina Nadya
AU - Ramadhani, Maura Tuzzahrah
AU - Puspamaniar, Vania Ayu
AU - Machin, Abdulloh
AU - Haryono, Yudha
N1 - Publisher Copyright:© 2024 The Author(s); This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC: https://creativecommons.org/licenses/by-nc/4.0/ legalcode.en), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
PY - 2024/10
Y1 - 2024/10
N2 - Background: The prevalence of Alzheimer disease (AD) is expected to increase, especially in Indonesia. Despite lacking a cure, extra-virgin olive oil, abundant in neuroprotective compounds, offers promise in delaying cognitive decline by opposing oxidative stress in the aging brain. Research indicates its capacity to bolster long-term cognitive function and memory. Objectives: We examined the impact of olive oil and its derivatives on AD through a comprehensive analysis of experimental studies in mouse and worm models. Materials & Methods: Thirteen relevant articles were selected from the initial pool based on specific inclusion criteria. Data were extracted regarding study design, intervention types, model species used, cognitive outcomes, and findings. The reliability of the selected studies was ensured by evaluating their methodological quality and risk of bias. Results: Our systematic review of 13 selected experimental studies involving mice and worm models provides insights into the potential impact of olive oil and its extracts on AD. Findings suggest that these interventions may exhibit neuroprotective properties, positively influencing cognitive function and mitigating AD-related outcomes in the experimental models studied. Conclusion: Experimental studies on mice and worm models suggest that olive oil and its extracts may present neuroprotective benefits and positively influence cognitive function in AD contexts. Further research involving human subjects is essential to validate these findings and explore their practical implications in AD prevention and management.
AB - Background: The prevalence of Alzheimer disease (AD) is expected to increase, especially in Indonesia. Despite lacking a cure, extra-virgin olive oil, abundant in neuroprotective compounds, offers promise in delaying cognitive decline by opposing oxidative stress in the aging brain. Research indicates its capacity to bolster long-term cognitive function and memory. Objectives: We examined the impact of olive oil and its derivatives on AD through a comprehensive analysis of experimental studies in mouse and worm models. Materials & Methods: Thirteen relevant articles were selected from the initial pool based on specific inclusion criteria. Data were extracted regarding study design, intervention types, model species used, cognitive outcomes, and findings. The reliability of the selected studies was ensured by evaluating their methodological quality and risk of bias. Results: Our systematic review of 13 selected experimental studies involving mice and worm models provides insights into the potential impact of olive oil and its extracts on AD. Findings suggest that these interventions may exhibit neuroprotective properties, positively influencing cognitive function and mitigating AD-related outcomes in the experimental models studied. Conclusion: Experimental studies on mice and worm models suggest that olive oil and its extracts may present neuroprotective benefits and positively influence cognitive function in AD contexts. Further research involving human subjects is essential to validate these findings and explore their practical implications in AD prevention and management.
KW - Alzheimer disease
KW - Dementia
KW - Experimental animal models
KW - Olive oil
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85209083102&partnerID=8YFLogxK
U2 - 10.32598/CJNS.10.39.471.1
DO - 10.32598/CJNS.10.39.471.1
M3 - Review article
AN - SCOPUS:85209083102
SN - 2383-4307
VL - 10
SP - 266
EP - 277
JO - Caspian Journal of Neurological Sciences
JF - Caspian Journal of Neurological Sciences
IS - 4
ER -
Sugondo AT, Salfi QN, Ramadhani MT, Puspamaniar VA, Machin A, Haryono Y. Olive Oil and Its Extracts in Alzheimer's Disease: A Systematic Review in Animal Models. Caspian Journal of Neurological Sciences. 2024 Oct;10(4):266-277. doi: 10.32598/CJNS.10.39.471.1
